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Myosin X and Cytoskeletal Reorganization
Applied Microscopy 2018;48:33-42
Published online June 30, 2018
© 2018 Korean Society of Microscopy.

Mitsuo Ikebe*, Osamu Sato, Tsuyoshi Sakai

Department of Cellular and Molecular Biology, University of Texas Health Science Center at Tyler, Tyler, TX 75708-3154, USA
Correspondence to: Ikebe M, http://orcid.org/0000-0002-8299-6643, Tel: +1-903-877-7785, Fax: +1-903-877-7316, E-mail: Mitsuo.Ikebe@uthct.edu
Received April 11, 2018; Revised May 31, 2018; Accepted June 19, 2018.
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Myosin X is one of myosin superfamily members having unique cellular functions on cytoskeletal reorganization. One of the most important cellular functions of myosin X is to facilitate the formation of membrane protrusions. Since membrane protrusions are important factors for diverse cellular motile processes including cell migration, cell invasion, path-finding of the cells, intercellular communications and so on, it has been thought that myosin X plays an important role in various processes that involve cytoskeletal reorganization including cancer progression and development of neuronal diseases. Recent studies have revealed that the unique cellular function of myosin X is closely correlated with its unique structural characteristics and motor properties. Moreover, it is found that the molecular and cellular activities of myosin X are controlled by its specific binding partner. Since recent studies have revealed the presence of various specific binding partners of myosin X, it is anticipated that the structural, biochemical and cell biological understanding of the binding partner dependent regulation of myosin X function can uncover the role of myosin X in diverse cell biological processes and diseases.
Keywords : Myosin X, Motor proteins, Processive movement, Membrane protrusions, Cytoskeletal structure


June 2018, 48 (2)
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Funding Information
  • National Institutes of Health(NIH)
      10.13039/100000002
      DC006103, AR048898, AR048526, HL073050, HL111696
  • Science Central
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