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Structural Studies of Respirasome by Cryo-Electron Microscopy
Applied Microscopy 2018;48:81-6
Published online December 28, 2018
© 2018 Korean Society of Microscopy.

Tae Jin Jeon, Ho Min Kim1, and Seong Eon Ryu*

Department of Bioengineering, College of Engineering, Hanyang University, Seoul 04763, Korea, 1Graduate School of Medical Science & Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea
Correspondence to: Ryu SE, http://orcid.org/0000-0003-3335-326X, Tel: +82-2-2220-4020, Fax: +82-2-2220-4023, E-mail: ryuse@hanyang.ac.kr
Received October 25, 2018; Revised November 21, 2018; Accepted November 22, 2018.
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract

The respiratory chain complex forms a supercomplex (SC) in the inner mitochondrial membrane. This complex facilitates the process of electron transfer to produce the proton gradient used to synthesize ATP. Understanding the precise structure of the SC is considered an important challenge. However, it has not yet been reported. The development of a Cryo-electron microscopy (EM) technique provides an effective way to obtain high-resolution micrographs to determine the high-resolution three-dimensional structure of biomolecules. In this brief review, the currently reported Cryo-EM structures of the mammalian respirasome have been described in order to establish a direction for further research in the respiratory system.

Keywords : Cryo-electron microscopy, Biomolecule structure, Respiratory chain complex, Respirasome


December 2018, 48 (4)
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