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The Effect of Rutin on Antioxidant and Anti-inflammation in Streptozotocin-induced Diabetic Rats
Applied Microscopy 2013;43:54-64
Published online June 30, 2013
© 2013 Korean Society of Microscopy.

Yoon Jeong Lee1,2, Kyung Hee Jeune1,*

1Department of Life Sciences, Yeungnam University, Gyeongsan 712-749, Korea,2Department of Optometry & Vision Science, Kyungwoon University, Gumi 730-739, Korea
Correspondence to: Jeune KH,
Tel: +82-53-810-3571
Fax: +82-53-810-4681
E-mail: khjeune@yu.ac.kr
Received April 14, 2013; Revised June 10, 2013; Accepted June 12, 2013.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
The study examined the antioxidant activities and anti-inflammatory effects of rutin from the streptozotocin (STZ)-induced diabetic rats. Results revealed that the levels of plasma glucose and serum glucose were remarkably higher in the STZ-treated group compared to other groups and were significantly reduced in the STZ+rutin treated group compared to the STZ-treated group. In terms of weight, it significantly increased in all experimental groups during the experiment period except for STZ-induced diabetic group. The weight of the STZ-treated group was remarkably reduced compared to other groups. Regarding the weight of each body organ, the STZ-treated group showed higher organ weight compared to the other groups while STZ+rutin-treated group showed significantly reduced kidney and liver weights compared to those of STZ-treated group. In the pancreas tissue of the STZ-treated group, β-cell destruction and vacuolization were observed. Inflammation in the heart, liver, kidney, and retina tissues were also vividly recorded. In the STZ+rutin administered group, the heart and retina tissues were shown to be preserved normally while the liver and kidney tissues showed reduced histopathology in general compared to the STZ-treated group. Conclusionally, the rutin has the effect on the antioxidant activities and anti-inflammation in the STZ-induced diabetic rats.
Keywords : Rutin, Diabetic rats, Streptozocin, Antioxidant, Anti-inflammation
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